云顶国际yd222

云顶国际yd222
师资力量

陈善勇     副教授

研究方向:化学生物学

联系方式:          Email:chensy@scu.edu.cn

个人主页:点击进入

简历:

学习经历

1996/9-2000/7,云顶国际yd222,学士

2002/9-2005/7,云顶国际yd222,硕士,导师:余孝其

2006/9-2010/12,云顶国际yd222,在职博士,导师:余孝其

工作经历

2005/7-2007/7,云顶国际yd222,助教

2007/7-2015/9,云顶国际yd222,讲师

2015/9-至今,云顶国际yd222,副教授

2013/11-2014/11,美国弗吉尼亚大学,访问学者,师从蒲林教授

主要研究方向

绿色合成方法学:集中于利用简单金属盐做催化剂来构建碳-碳,碳-杂原子键。

荧光探针:构建新型荧光分子,用于生物体内成像

主要工作业绩

在有机合成方面,发展了简单钴、铜、铁金属盐催化碳氢的直接官能团化反应,并将其用于重要杂环化合物的合成,2篇论文入选高被引论文。研究成果“简单金属盐催化的C-CC-N键形成反应2011年获得获教育部自然科学一等奖(排名第四)。在荧光探针方面, 利用新的方法构建荧光分子,简化了合成路径,易于分离,并将这些荧光探针分子用生物体内一些活性物质或生命活动的追踪。

代表性成果 (获奖成果、专著、论文、专利)

1.  Chen, S.-Y.; Li Z.; Li, K. *; Yu, X. Q. *, Small molecular fluorescent probes for the detection of lead, cadmium and mercury ions, Coord. Chem. Rev.2021, 429, 213619. DOI: 10.1016/j.ccr.2020.213691.

2.  Yu, K. K.; Pan, S.-L.; Li, K.; Shi, L.; Liu, Y.-H.; Chen, S.-Y.*; Yu, X.-Q. *, A novel near-infrared fluorescent sensor for zero background nitrite detection via the "covalent-assembly" principle, Food Chem., 2021, 341, 128254.

3.  He, H.-Z.; Li, K.; Yu, K.-K.; Lu, P,-L.; Feng, M.-L. Chen, S.-Y.*; Yu, X.-Q. *,Additive- and column-free synthesis of rigid biscoumarins as fluorescent dyes for G-quadruplex sensing via disaggregation-induced emission, Chem. Commun., 2020,56, 6870.

4. Feng, M.-L.; L, S.-Q.; He, H.-Z.; Xi, L.-Y.; Chen, S.-Y.*; Yu, X.-Q. *, Electrochemically initiated intermolecular C–N formation/cyclization of ketones with 2-aminopyridines: an efficient method for the synthesis of imidazo[1,2-a]pyridines, Green Chem., 2019, 21,1619.

5.  Wang, S.; Chen, S.-Y.*; Yu, X.-Q.*, C-H   functionalization by high-valent Cp*Co(III) catalysis. Chem. Commun. 2017, 53, 3165-3180.

6.  Feng, M.-L.; Xi, L.-Y.; Chen, S.-Y.*; Yu, X.-Q.*,   Electrooxidative Metal-Free Dehydrogenative alpha-Sulfonylation of 1H-Indole with Sodium Sulfinates.  Eur, J. Org. Chem. 2017, 2746-2750.

7.  Zhang, R.-Y.; Xi, L.-Y.; Shi, L.; Zhang, X.-Z.; Chen, S.-Y.*; Yu, X.-Q.*, Metal-Free Oxidative Radical Alkynylation/Ring Expansion Rearrangement of AlkenylCyclobutanols with Ethynylbenziodoxolones. Org. Lett. 2016, 18, 4024-4027.

8.  Wang, S.; Hou, J.-T.; Feng, M.-L.; Zhang, X.-Z.; Chen, S.-Y.*; Yu, X.-Q.*, Cobalt(III)-catalyzed alkenylation of arenes  and 6-arylpurines with terminal alkynes: efficient access to functional dyes. Chem.Commun. 2016, 52, 2709-2712.

9.  Chen, S.-Y.; Liu, W.; Wu, X.; Ying, J.; Yu, X.-Q*;   Pu, L.*, A Lewis acid activated reaction of Zn with EtI to promote highly   enantioselective alkyne additions to aldehydes. Chem. Commun. 2015, 51, 358-361.

10. Xi, L.-Y.; Zhang, R.-Y.; Liang, S.; Chen, S.-Y.*; Yu, X.-Q.*, Copper-Catalyzed Aerobic Synthesis of 2-Arylpyridines from Acetophenones and 1,3-Diaminopropane. Org. Lett. 2014, 16, 5269-5271.

11.  Wang, S.; Guo, R.; Wang, G.; Chen, S.-Y.*; Yu, X.-Q.*,  Copper-catalyzed phosphorylation of sp(2) C-H bonds. Chem. Commun. 2014, 50, 12718-12721.

12.  Wang, G.; Yu, Q.-Y.; Chen, S.-Y.*; Yu, X.-Q.*, Et4NI-catalyzed amidationof aldehydes and alcohols with ammonium salts. Org. Biomol. Chem. 2014, 12, 414-417.

13.  Liang, S.; Zhang, R.-Y.; Xi, L.-Y.; Chen, S.-Y.*; Yu, X.-Q.*, Sulfonylationof Five-Membered Heterocycles via anSNAr Reaction. J. Org. Chem. 2013,78, 11874-11880.

14.  Liang, S.; Zhang, R.-Y.; Wang, G.; Chen, S.-Y.*; Yu, X.-Q.*, Transition-Metal-Free Synthesis of (E)-Vinyl Sulfones from Vinyl Halides in Water. Eur. J. Org. Chem. 2013, 7050-7053.

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